Changes in the Structure of the Benzylpenicillin Sodium Salt Molecule under the Pulsed Magnetic Field

Natalia A. Rodenko; Valentina A. Zhukova; Tatyana I. Vasilieva; Vladimir A. Glushchenkov; Irina A. Belyaeva

doi:10.18287/JBPE21.07.010305

Authors

Natalia A. Rodenko Samara National Research University, Russia Samara Federal Research Centre of the Russian Academy of Sciences, Russia
Valentina A. Zhukova Samara National Research University, Russia
Tatyana I. Vasilieva Samara National Research University, Russia
Vladimir A. Glushchenkov Samara National Research University, Russia Samara Federal Research Centre of the Russian Academy of Sciences, Russia
Irina A. Belyaeva Samara National Research University, Russia Samara Federal Research Centre of the Russian Academy of Sciences, Russia

DOI:

https://doi.org/10.18287/JBPE21.07.010305

Keywords:

antibiotic, Fourier spectroscopy, magnetic field intensity, biological activity

Abstract

The study aims at the Fourier spectra of an antibiotic exposed to a high-intensity pulsed magnetic field. The applied frequency was f = 40 kHz, with a number of pulses n = 1, at intensities of the pulsed magnetic field H = 0.09 × 10⁶ А/m, Н = 0.50 × 10⁶ А/m, Н = 0.82 × 10⁶ А/m. It was assumed that under the conditions of the pulsed magnetic field there might be a change in the structure of the drug molecule. The research has revealed that an increase in the pulsed magnetic field power leads first to a decrease in the intensity of the band in the Fourier spectrum, and then to its increase. In addition, changes were recorded in the amide group of benzylpenicillin sodium salt molecules depending on the intensity of the pulsed magnetic field applied to the antibiotic.

Author Biographies

Natalia A. Rodenko, Samara National Research University, Russia Samara Federal Research Centre of the Russian Academy of Sciences, Russia

Design Engineer Research Laboratory for Progressive Technological Processes of Plastic Deformation-41
Valentina A. Zhukova, Samara National Research University, Russia

Associate Professor Department of Optics and Spectroscopy
Tatyana I. Vasilieva, Samara National Research University, Russia

Associate Professor Department of Biochemistry, Biotechnology and Bioengineering
Vladimir A. Glushchenkov, Samara National Research University, Russia Samara Federal Research Centre of the Russian Academy of Sciences, Russia

Professor Department of Metal Forming, Samara National Research University
Irina A. Belyaeva, Samara National Research University, Russia Samara Federal Research Centre of the Russian Academy of Sciences, Russia

Associate Professor Department of Metal Forming, Samara National Research University

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